Thermo Fisher Scientific SURF1 Polyclonal Antibody
Thermo Fisher Scientific의 SURF1 Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하며 Western blot과 ELISA에 적합합니다. Recombinant SURF1 단백질(aa 80–275)을 면역원으로 사용한 rabbit IgG 폴리클로날 항체로, 액상 형태이며 -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 80–275 of human SURF1 (NP_003163.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.15 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855859 |
Product Specific Information
Immunogen sequence:
QVQRRKWKLN LIAELESRVL AEPVPLPADP MELKNLEYRP VKVRGCFDHS KELYMMPRTM VDPVREAREG GLISSSTQSG AYVVTPFHCT DLGVTILVNR GFVPRKKVNP ETRQKGQIEG EVDLIGMVRL TETRQPFVPE NNPERNHWHY RDLEAMARIT GAEPIFIDAN FQSTVPGGPI GGQTRVTLRN EHLQYI
Target Information
The SURF-1 protein plays a vital role in the assembly of complex IV (CIV or COX) of the mitochondrial respiratory chain. It is expressed in the inner mitochondrial membrane, and mutations in the SURF-1 gene cause cytochrome c oxidase complex IV deficiency, leading to Leigh syndrome—a severe neurological disorder characterized by necrotic lesions in subcortical brain regions.
SURF-1 mutations are associated with high embryonic lethality and early postnatal mortality, as well as muscle weakness and motor deficits. Morphological abnormalities in heart, brain, and skeletal muscle frequently occur due to SURF-1 dysfunction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-110448_SURF1_Q15526-1_Rabbit.svg, PA5-110448_SURF1_Q15526-1_Rabbit_PDP.jpeg)
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