Thermo Fisher Scientific SURF1 Polyclonal Antibody
Thermo Fisher Scientific의 SURF1 Polyclonal Antibody는 인간, 생쥐, 랫트에서 반응하며 Western blot 및 ELISA에 사용 가능합니다. 고순도 rabbit IgG 항체로, PBS/glycerol buffer에 보존되며 mitochondrial complex IV 관련 연구에 적합합니다.
- 카탈로그번호
- PA5110449
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 80–275 of human SURF1 (NP_003163.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.21 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855860 |
Product Specific Information
Immunogen sequence:
QVQRRKWKLN LIAELESRVL AEPVPLPADP MELKNLEYRP VKVRGCFDHS KELYMMPRTM VDPVREAREG GLISSSTQSG AYVVTPFHCT DLGVTILVNR GFVPRKKVNP ETRQKGQIEG EVDLIGMVRL TETRQPFVPE NNPERNHWHY RDLEAMARIT GAEPIFIDAN FQSTVPGGPI GGQTRVTLRN EHLQYI
Target Information
The SURF-1 protein plays a vital role in the assembly of complex IV (CIV or COX) in the mitochondrial respiratory chain. It is expressed in the inner mitochondrial membrane, and mutations in the SURF-1 gene cause cytochrome c oxidase complex IV deficiency, often leading to Leigh syndrome—a severe neurological disorder characterized by necrotic lesions in subcortical brain regions.
SURF-1 mutations are associated with high embryonic lethality and early postnatal mortality, as well as muscle weakness and motor impairment due to defects in skeletal muscle and liver. Morphological abnormalities in heart, brain, and skeletal muscle frequently occur in SURF-1 mutation cases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-110449_SURF1_Q15526-1_Rabbit.svg)
(이미지: PA5-110449_SURF1_Q15526-1_Rabbit_PDP.jpeg)
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