Thermo Fisher Scientific SURF1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
QVQRRKWKLN LIAELESRVL AEPVPLPADP MELKNLEYRP VKVRGCFDHS KELYMMPRTM VDPVREAREG GLISSSTQSG AYVVTPFHCT DLGVTILVNR GFVPRKKVNP ETRQKGQIEG EVDLIGMVRL TETRQPFVPE NNPERNHWHY RDLEAMARIT GAEPIFIDAN FQSTVPGGPI GGQTRVTLRN EHLQYI

Target Information

The SURF-1 protein plays a vital role in the assembly of complex IV (CIV or COX) in the mitochondrial respiratory chain. It is expressed in the inner mitochondrial membrane, and mutations in the SURF-1 gene cause cytochrome c oxidase complex IV deficiency, often leading to Leigh syndrome—a severe neurological disorder characterized by necrotic lesions in subcortical brain regions.
SURF-1 mutations are associated with high embryonic lethality and early postnatal mortality, as well as muscle weakness and motor impairment due to defects in skeletal muscle and liver. Morphological abnormalities in heart, brain, and skeletal muscle frequently occur in SURF-1 mutation cases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지: PA5-110449_SURF1_Q15526-1_Rabbit.svg)
(이미지: PA5-110449_SURF1_Q15526-1_Rabbit_PDP.jpeg)