Thermo Fisher Scientific ETS1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.5 µg/mL

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

ETS1 (c-Ets-1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); ETS-1; EWSR2; p54) is a 441 amino acid protein belonging to the DNA-binding ETS family.
It consists of:

• N-terminal pointed domain
• Central transactivation domain
• Two auto-inhibitory domains flanked by conserved C-terminal ETS domain

ETS1 interacts with factors such as PEBP2alphaA and p300/CBP, mediating transactivation of Osteopontin, Presenilin-1, Stromelysin, and Collagenase.
Activated by Ras/MAPK signaling, its expression increases in resting T-cells.
Activity is modulated by AP-1, Sp-1, c-myb, and MafB.
Sp100 activates ETS1 in nuclear bodies.
Interacts with EAP1/Daxx (represses MMP1 and BCL2 transactivation), STAT6 (modulates Socs-1 expression induced by IL-4), and GATA3 (positively regulates Tax-1 dependent IL-5 expression).

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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