Thermo Fisher Scientific SIX5 Polyclonal Antibody
SIX5 단백질을 표적으로 하는 Thermo Fisher Scientific의 rabbit polyclonal antibody로, Western blot에 적합합니다. Human, Mouse, Rat 반응성이 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 1 mg/mL 농도, PBS buffer에 sodium azide 포함.
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Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 205–256 of Human Six5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term storage, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2719145 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
Six5 (homeobox protein SIX5), also known as SIX5, BOR2 or DMAHP, is a transcription factor expressed in various structures of the adult eye.
During development, it localizes to the cytoplasm early and the nucleus later, regulating organogenesis and retinal formation.
Six5 binds the 5'-TCA[AG][AG]TTNC-3' DNA sequence found in the myogenin and IGFBP5 promoters, controlling transcription of associated mRNA.
It interacts with DACH1 and is co-activated by EYA proteins.
Mutations in Six5 cause branchio-oto-renal syndrome type 2 (BOR2), characterized by hearing loss, deep overbite, and myopia.
Two isoforms exist due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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