Thermo Fisher Scientific Nkx2.6 Polyclonal Antibody
Rabbit polyclonal antibody targeting Nkx2.6, validated for Western blot in human, mouse, and rat. Affinity-purified with >95% purity. Supplied as liquid, 1 mg/mL in PBS with 0.05% sodium azide. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 111–160 of Human Nkx2.6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2719144 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by epitope-specific affinity chromatography. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
Members of the NK-2 family of homeodomain proteins are key regulators of growth and development in several tissues, including brain, heart, and pancreas. Nkx-2.5, also known as cardiac specific homeobox protein (Csx), is a homolog of the Drosophila tinman protein and is essential for normal cardiovascular development. Expression of Nkx-2.5 during cardiomyogenesis is required for cardiac septation.
Nkx-2.5 binds to DNA as a monomer, homodimer, or heterodimer with Nkx-2.3 or Nkx-2.6, indicating that specific protein-protein interactions are critical for its transcriptional regulatory function. Nkx-2.6, another homolog of the Drosophila tinman protein, is expressed in the caudal pharyngeal pouches, caudal heart progenitors, sinus venosus, outflow tract of the heart, and a short segment of the gut between embryonic stages E8.5 and E10.5. Expression of Nkx-2.6 overlaps with Nkx-2.5 in the pharynx and heart. Nkx-2.6 mutant mice are viable and fertile, suggesting a compensatory role for Nkx-2.5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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