Thermo Fisher Scientific MAPKAPK3 Polyclonal Antibody

Applications

• Western Blot (WB): 1:1,000

Product Specifications

Product Specific Information

• It is not recommended to aliquot this antibody.
• This antibody is not cross-reactive with MAPKAPK-2 or -5.

Target Information

MAPKAPK3 functions as an integrative element of signaling in both mitogen and stress responses. It acts as a mitogen-activated protein kinase (MAP kinase)-activated protein kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), serve as integration points for multiple biochemical signals. MAPKAPK3 is activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase, and Jun N-terminal kinase can phosphorylate and activate this kinase, suggesting its role as an integrative element in both mitogen and stress signaling. MAPKAPK3 interacts with, phosphorylates, and represses the activity of E47, a basic helix-loop-helix transcription factor involved in tissue-specific gene expression and cell differentiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.