Thermo Fisher Scientific MAPKAPK3 Polyclonal Antibody
MAPKAPK3 단백질을 인식하는 토끼 다클론 항체로, Western blot에 적합합니다. 인간, 영장류, 랫드 시료에서 반응하며 MAPKAPK-2 및 -5와 교차 반응하지 않습니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 -20°C에서 보관합니다.
- 카탈로그번호
- PA517270
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the amino-terminal region of human MAPKAPK-3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10980846 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with MAPKAPK-2 or -5.
Target Information
MAPKAPK3 functions as an integrative element of signaling in both mitogen and stress responses. It acts as a mitogen-activated protein kinase (MAP kinase)-activated protein kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), serve as integration points for multiple biochemical signals. MAPKAPK3 is activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase, and Jun N-terminal kinase can phosphorylate and activate this kinase, suggesting its role as an integrative element in both mitogen and stress signaling. MAPKAPK3 interacts with, phosphorylates, and represses the activity of E47, a basic helix-loop-helix transcription factor involved in tissue-specific gene expression and cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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