Thermo Fisher Scientific MAVS Polyclonal Antibody
MAVS 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, ICC/IF, IP 등 다양한 응용에 적합. Mouse 및 Rat 시료 반응성. 액상 형태로 제공되며 -20°C에서 보관. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50 |
| Immunoprecipitation (IP) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding Cys140 of mouse MAVS/VISA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10982305 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway relies on members of the Toll-like receptor (TLR) family, while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA to trigger the immune response.
MAVS is a mitochondrial membrane protein critical in IFN beta signaling, recruiting IRF-3 to RIG-I and activating NF-kappa-B. It interacts with innate immunity components such as TRIF, TRAF2, and TRAF6, and also with kinases IKK-alpha, IKK-beta, and IKK-iota through its C-terminal region. Cleavage of this region by the Hepatitis C virus protease allows viral immune evasion. Multiple isoforms of MAVS are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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