Thermo Fisher Scientific Spectrin beta III (SPTBN2) Recombinant Rabbit Monoclonal Antibody (SPTBN2/2894R)
Spectrin beta III(SPTBN2)을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, Flow cytometry, ELISA에 사용 가능. HEK293 세포에서 발현된 IgG 형식의 항체이며, 단백질 A/G 정제. 인체 반응성, 보존제 무첨가 PBS 용액 형태.
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- 6712-RBM7-P1ABX
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| ELISA | 2–4 µg/mL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SPTBN2/2894R |
| Immunogen | Recombinant human SPTBN2 fragment (aa356–475) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Spectrins are principal components of the cell membrane–cytoskeleton and are composed of two alpha and two beta spectrin subunits.
The SPTBN2 gene encodes spectrin beta non-erythrocytic 2 (beta-III spectrin), which is related to but distinct from beta-II spectrin (SPTBN1).
SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the plasma membrane surface.
Mutations in SPTBN2 cause spinocerebellar ataxia type 5 (SCA5), characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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