Thermo Fisher Scientific Spectrin beta III (SPTBN2) Recombinant Rabbit Monoclonal Antibody (SPTBN2/2894R)
Spectrin beta III(SPTBN2) 단백질을 인식하는 Thermo Fisher Scientific의 재조합 토끼 단일클론 항체로, WB, IHC, Flow, ELISA 등 다양한 응용에 적합합니다. 인간 시료 반응성이 있으며, HEK293 발현 시스템에서 생산된 고순도 항체로 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| ELISA | 2–4 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SPTBN2/2894R |
| Immunogen | Recombinant human SPTBN2 fragment (aa356–475) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Spectrins are principal components of the cell membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits.
The protein encoded by SPTBN2 (spectrin beta non-erythrocytic 2 or beta-III spectrin) is related to, but distinct from, the beta-II spectrin gene (SPTBN1).
SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the plasma membrane surface.
Mutations in this gene cause spinocerebellar ataxia type 5 (SCA5), characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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