Thermo Fisher Scientific Spectrin beta III (SPTBN2) Recombinant Rabbit Monoclonal Antibody (SPTBN2/2887R)
Spectrin beta III(SPTBN2)에 특이적인 Thermo Fisher의 재조합 토끼 단클론 항체로, WB, IHC, ICC/IF, Flow Cytometry에 적합합니다. HEK293 세포에서 발현되었으며, Protein A/G로 정제된 1 mg/mL 액상 형태 제품입니다. 인간 시료에 반응하며, -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SPTBN2/2887R |
| Immunogen | Recombinant human SPTBN2 fragment (aa 356–475) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Spectrins are principal components of the cell membrane-cytoskeleton, composed of two alpha and two beta spectrin subunits. The SPTBN2 gene encodes spectrin beta non-erythrocytic 2 (beta-III spectrin), which regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the plasma membrane. Mutations in SPTBN2 are associated with spinocerebellar ataxia type 5 (SCA5), characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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