Thermo Fisher Scientific NSD1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

ELISA

• Tested Concentration: 1 µg/mL

Product Specifications

Product Specific Information

Positive test controls include: 293T, A-549, MCF7, SW480, Mouse kidney, Mouse lung.
The target is usually localized in the Chromosome and Nucleus.

Immunogen sequence:
AYGQDSPSCY IPLRRLQDLA SMINVEYLNG SADGSESFQD PEKSDSRAQT PIVCTSLSPG GPTALAMKQE PSCNNSPELQ VKVTKTIKNG FLHFENFTCV DDADVDSEMD PEQPVTEDES IEEIFEETQT NATCNYETKS ENGVKVAMGS EQDSTPESRH GAVKSPFLPL APQTETQKNK QRNEVDGSNE KAALLPAPFS L

Target Information

The NSD1 gene encodes a protein containing:

• SET domain
• 2 LXXLL motifs
• 3 nuclear translocation signals (NLSs)
• 4 plant homeodomain (PHD) finger regions
• Proline-rich region

This protein enhances androgen receptor (AR) transactivation, further increased in the presence of AR-associated coregulators. It may function as a nucleus-localized transcriptional factor and bifunctional transcriptional regulator.
Mutations are associated with Sotos syndrome and Weaver syndrome.
A subtype of childhood acute myeloid leukemia results from a cryptic translocation between NSD1 (chromosome 5) and NUP98 (chromosome 11).
Two transcript variants encoding distinct isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.