Thermo Fisher Scientific NSD1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human and mouse NSD1 protein. Validated for WB and ELISA applications. High purity via affinity chromatography with 1.97 mg/mL concentration. Supplied in PBS buffer with 50% glycerol for stable long-term storage.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 60–260 of human NSD1 (NP_071900.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.97 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914824 |
Product Specific Information
Positive test controls include: 293T, A-549, MCF7, SW480, Mouse kidney, Mouse lung.
The target is usually localized in the Chromosome and Nucleus.
Immunogen sequence:
AYGQDSPSCY IPLRRLQDLA SMINVEYLNG SADGSESFQD PEKSDSRAQT PIVCTSLSPG GPTALAMKQE PSCNNSPELQ VKVTKTIKNG FLHFENFTCV DDADVDSEMD PEQPVTEDES IEEIFEETQT NATCNYETKS ENGVKVAMGS EQDSTPESRH GAVKSPFLPL APQTETQKNK QRNEVDGSNE KAALLPAPFS L
Target Information
The NSD1 gene encodes a protein containing:
- SET domain
- 2 LXXLL motifs
- 3 nuclear translocation signals (NLSs)
- 4 plant homeodomain (PHD) finger regions
- Proline-rich region
This protein enhances androgen receptor (AR) transactivation, further increased in the presence of AR-associated coregulators. It may function as a nucleus-localized transcriptional factor and bifunctional transcriptional regulator.
Mutations are associated with Sotos syndrome and Weaver syndrome.
A subtype of childhood acute myeloid leukemia results from a cryptic translocation between NSD1 (chromosome 5) and NUP98 (chromosome 11).
Two transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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