Thermo Fisher Scientific NSD1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 60-260 of human NSD1 (NP_071900.2). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NSD1,uniProtId:Q96L73-1,ncbiNodeId:9606,antigenRange:60-260,antigenLength:2696,antigenImageFileName:PA5-121252_NSD1_Q96L73-1_Rabbit.svg,antigenImageFileNamePDP:PA5-121252_NSD1_Q96L73-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.97 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914824

Product Specific Information

Positive test controls include: 293T, A-549, MCF7, SW480, Mouse kidney, Mouse lung. The target is usually found in the following locations: Chromosome, Nucleus.

Immunogen sequence: AYGQDSPSCY IPLRRLQDLA SMINVEYLNG SADGSESFQD PEKSDSRAQT PIVCTSLSPG GPTALAMKQE PSCNNSPELQ VKVTKTIKNG FLHFENFTCV DDADVDSEMD PEQPVTEDES IEEIFEETQT NATCNYETKS ENGVKVAMGS EQDSTPESRH GAVKSPFLPL APQTETQKNK QRNEVDGSNE KAALLPAPFS L

Target Information

This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.