Thermo Fisher Scientific ATM Polyclonal Antibody, DyLight 488
ATM 단백질을 인식하는 DyLight 488 결합 폴리클로날 항체로, 인간 등 다양한 종에 반응합니다. Western blot, IHC, ICC/IF, Flow cytometry 등 다중 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 형광 검출용으로 사용됩니다.
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Thermo Fisher Scientific ATM Polyclonal Antibody, DyLight 488
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Marsupial, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A fragment of human ATM protein expressed in E. coli, corresponding to the C-terminal region (within the last third of the protein sequence). |
| Conjugate | DyLight™ 488 |
| Excitation / Emission Max | 492 / 519 nm |
| Form | Liquid |
| Concentration | 1.47 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 50 mM sodium borate |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152836 |
Target Information
Ataxia-telangiectasia Mutated (ATM) is a protein that belongs to the PI3/PI4 kinase family. Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer. The ATM gene encodes a protein in the phosphoinositide 3-kinase (PI3K) superfamily. ATM phosphorylates proteins rather than lipids and regulates cell-cycle proteins such as P53, Mdm2, BRCA1, and SMC1.
ATM is critical for repairing double-stranded DNA breaks induced by ionizing radiation and mutagens. Its C-terminal region shares homology with catalytic domains of PI3 kinases. Upon ionizing radiation exposure, ATM becomes autophosphorylated and upregulated, initiating a cascade of kinase reactions that control cell cycle, apoptosis, and DNA damage repair. ATM has been linked to apoptosis via interactions with Nbs1 and Chk2 in the E2F1 pathway.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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