Thermo Fisher Scientific ATM Polyclonal Antibody, HRP
ATM 단백질을 표적으로 하는 Thermo Fisher Scientific의 HRP 결합 폴리클로날 항체. Western blot, IHC, ELISA 등 다양한 응용 가능. 인간, 마우스, 개 등 다종 반응성. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent | - |
| ELISA | Assay-Dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Marsupial, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A fragment of human ATM protein expressed in E. coli, corresponding to the C-terminal region (within the last third of the protein sequence). |
| Conjugate | HRP |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_11152318 |
Target Information
Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family.
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.
The ATM gene encodes a protein within the phosphoinositide 3-kinase (PI3K) superfamily. ATM phosphorylates proteins rather than lipids and regulates cell-cycle proteins such as P53, Mdm2, BRCA1, and SMC1.
ATM is essential for repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens. Its C-terminal region shares homology with catalytic domains of PI3 kinases.
ATM becomes autophosphorylated and upregulated upon exposure to ionizing radiation. AT cells are hypersensitive to radiation, impaired in DNA synthesis inhibition, and show delayed p53 induction. DNA damage activates ATM-kinase, initiating kinase cascades that regulate cell cycle, apoptosis, and DNA damage repair.
Studies have linked ATM to apoptosis along with Nbs1 and Chk2 in the E2F1 pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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