Thermo Fisher Scientific KCNQ4 Polyclonal Antibody
KCNQ4 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF 등 다양한 응용에 사용 가능. 인간 및 생쥐 반응성. 고순도 친화 크로마토그래피 정제, 1 mg/mL 농도. 신경 흥분성 조절 연구에 적합.
- 판매단위
- pk
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KCNQ4 (Accession P56696), corresponding to amino acid residues Q580–E630 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851199 |
Product Specific Information
Antibody detects endogenous levels of total KCNQ4.
Target Information
The protein encoded by this gene forms a potassium channel that plays a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form homomultimeric or heteromultimeric channels in association with KCNQ3. Defects in this gene cause nonsyndromic sensorineural deafness type 2, an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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