Thermo Fisher Scientific KCNQ5 Polyclonal Antibody
KCNQ5 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. Human 및 Mouse 시료에 반응하며, 1 mg/mL 농도의 액상 형태로 제공됩니다. Affinity chromatography로 정제되어 높은 특이성과 재현성을 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KCNQ5 (Accession Q9NR82), corresponding to amino acid residues L835–T885. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851200 |
Product Specific Information
Antibody detects endogenous levels of total KCNQ5.
Target Information
KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently, five KCNQs (KCNQ1–5) are known, primarily expressed in the central nervous system. KCNQ3 and KCNQ5 can form heteromultimers that significantly increase the M-current. Inhibition of this current regulates neuronal excitability and synaptic responsiveness.
Mutations in KCNQ genes are associated with disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain, and epilepsy. These voltage-dependent potassium channels play a critical role in maintaining resting membrane potential and modulating excitability of electrically active cells. They are typically tetrameric and may interact with auxiliary subunits that modify current properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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