Thermo Fisher Scientific Phospho-BRCA1 (Ser1423) Polyclonal Antibody

Thermo Fisher Scientific Phospho-BRCA1 (Ser1423) Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:2,000
• Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200

Product Specifications

Product Specific Information

This antibody detects endogenous levels of BRCA1 only when phosphorylated at Serine 1423.

Target Information

BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein involved in maintaining genomic stability and functioning as a tumor suppressor. It forms part of the BASC complex (BRCA1 associated genome surveillance complex), interacting with RNA polymerase II and histone deacetylase complexes. BRCA1 plays critical roles in transcription regulation, DNA repair of double-stranded breaks, and recombination.
Mutations in BRCA1 are responsible for approximately 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers. Alternative splicing affects its localization and function, with several disease-associated transcript variants identified. A related pseudogene exists on chromosome 17.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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