Thermo Fisher Scientific Phospho-BRCA1 (Ser1423) Polyclonal Antibody
BRCA1 단백질의 Ser1423 인산화 형태를 특이적으로 검출하는 폴리클로날 항체. Western blot 및 IHC(Paraffin) 분석에 적합. 인간 및 랫트 반응성. 고순도 정제 및 안정적 PBS/glycerol 저장 조건 제공.
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Thermo Fisher Scientific Phospho-BRCA1 (Ser1423) Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BRCA1 (Accession P38398), corresponding to amino acid residues around phosphorylated Ser1423 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816360 |
Product Specific Information
This antibody detects endogenous levels of BRCA1 only when phosphorylated at Serine 1423.
Target Information
BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein involved in maintaining genomic stability and functioning as a tumor suppressor. It forms part of the BASC complex (BRCA1 associated genome surveillance complex), interacting with RNA polymerase II and histone deacetylase complexes. BRCA1 plays critical roles in transcription regulation, DNA repair of double-stranded breaks, and recombination.
Mutations in BRCA1 are responsible for approximately 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers. Alternative splicing affects its localization and function, with several disease-associated transcript variants identified. A related pseudogene exists on chromosome 17.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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