Thermo Fisher Scientific Phospho-Alpha-synuclein (Tyr133) Polyclonal Antibody
인간, 마우스, 랫트에서 인산화된 Tyr133 알파-시뉴클레인을 특이적으로 검출하는 폴리클로날 항체. Western blot 및 면역세포염색에 적합하며, PBS/glycerol 완충액에 보관. 파킨슨병 및 알츠하이머 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SNCA (Accession P37840), corresponding to amino acid residues around phosphorylated Tyr133. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816359 |
Product Specific Information
This antibody detects endogenous levels of alpha-synuclein only when phosphorylated at Tyrosine 133.
Target Information
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein selectively inhibit phospholipase D2, suggesting involvement in signaling pathways.
Defects in the SNCA gene, encoding alpha-synuclein, are implicated in the pathogenesis of Parkinson’s disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in Alzheimer’s disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Diseases associated with SNCA include Parkinson Disease 1 (Autosomal Dominant) and Lewy Body Dementia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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