Thermo Fisher Scientific TWIST1 Polyclonal Antibody
TWIST1 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC, ICC/IF에 사용 가능하며, 고순도의 액상 형태로 제공됩니다. Affinity chromatography로 정제되었으며, 연구용으로 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | 1:100–1:500 | View 2 publications |
| Immunocytochemistry (ICC/IF) | – | View 1 publication |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein of Twist (aa 1–100) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2635141 |
Product Specific Information
This antibody detects endogenous levels of total TWIST1 protein.
Target Information
TWIST1 functions as a transcriptional regulator. It inhibits myogenesis by sequestering E proteins, suppresses trans-activation by MEF2, and interferes with MYOD1 DNA-binding through physical interaction. Additionally, TWIST1 represses proinflammatory cytokines such as TNFA and IL1B and plays a key role in cranial suture patterning and gene expression regulation depending on dimer composition.
Mutations in TWIST1 are associated with Saethre-Chotzen syndrome, characterized by craniosynostosis, brachycephaly, facial asymmetry, and other craniofacial abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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