Thermo Fisher Scientific WASP Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000 dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total WASP protein.

Target Information

The Wiskott-Aldrich syndrome family of proteins share similar domain structures and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. These proteins interact with multiple signaling molecules, including the small GTPase Cdc42 and the cytoskeletal organizing complex Arp2/3.
Wiskott-Aldrich syndrome is a rare, inherited, X-linked recessive disease characterized by immune dysregulation and microthrombocytopenia, caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein expressed exclusively in hematopoietic cells, showing signaling and cytoskeletal abnormalities in affected patients.
A transcript variant with an alternative promoter and different 5′ UTR sequence has been described, though its full-length nature remains unknown.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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