Thermo Fisher Scientific Leptin Receptor (LEPR)/Ob-R/CD295 Monoclonal Antibody (LEPR/4304)

Applications and Tested Dilution

Product Specifications

Target Information

The leptin (OB-R) receptor is a member of the cytokine receptor superfamily that plays an important role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of the OB-R by the adipose tissue-secreted hormone leptin triggers downstream signaling through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway.

Leptin can homo-dimerize OB-R extracellular domains, initiating signaling via intracellular domain dimerization. Multiple isoforms of OB-R with different signaling capabilities have been identified. RNA transcripts encoding the long form of OB-R are found in the choroid plexus and hypothalamus, proposed as centers for satiety and energy expenditure regulation.

Mutations in mouse OB-R (db) or leptin (ob) genes lead to early-onset obesity and metabolic abnormalities such as hypercorticoidemia, hyperinsulinemia, insulin resistance, hyperglycemia, altered CNS activity, reduced brown adipose tissue metabolism, and increased white adipose tissue.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.