Thermo Fisher Scientific Glycine Receptor alpha 1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Reconstitution: Add 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
The reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and store at -20°C. Avoid multiple freeze/thaw cycles.
Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

GLRA1 is a subunit of a pentameric inhibitory glycine receptor that mediates postsynaptic inhibition in the central nervous system.
Defects in GLRA1 cause startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome.
Multiple transcript variants encoding different isoforms have been identified.
Glycine receptors containing GLRA1 are members of the cys-loop family of ligand-gated ion channels, mediating the inhibitory effects of glycine.
GLRA1 is widely distributed throughout the CNS, particularly within the hippocampus, spinal cord, and brain stem.
Diseases associated with GLRA1 include hereditary hyperekplexia types 1 and related disorders.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.