Thermo Fisher Scientific PSME1 Recombinant Rabbit Monoclonal Antibody (29D5)

Applications and Tested Dilution

Product Specifications

Target Information

Proteolytic degradation is critical for maintaining appropriate levels of short-lived and regulatory proteins involved in cellular metabolism, stress response, antigen presentation, receptor modulation, ion channels, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cytosol and nucleus, while others are degraded via the vacuolar pathway involving endosomes, lysosomes, and the endoplasmic reticulum.

The 26S proteasome is an ATP-dependent, multisubunit (approx. 31), barrel-shaped molecular complex (~2.5 MDa) composed of a 20S proteolytic core and one or two 19S regulatory subunits. The 19S subunits recognize ubiquitinated proteins and assist in unfolding and translocating them into the 20S lumen.

An enzymatic cascade attaches multiple ubiquitin molecules to lysine residues of target proteins for degradation. Defects in this pathway are associated with genetic diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.