Thermo Fisher Scientific STAT4 Recombinant Rabbit Monoclonal Antibody (26G2)

Applications and Tested Dilution

Product Specifications

Target Information

STAT4 was originally identified using degenerate primers complementary to sequences encoding conserved regions of other STAT proteins. The STAT4 protein is most similar to STAT1 (52%) and STAT3 (47%). Functionally, STAT4 can be tyrosine phosphorylated by Jak1 or Jak2 and forms homodimers and heterodimers with related STAT family members. Tyrosine phosphorylated STAT4 can bind the IFN-gamma activated site (GAS), and serine phosphorylation is required for maximal transcriptional activity.

STAT4 expression is restricted to the thymus, spleen, and testis. It is activated by interleukin 12 (IL-12), which is required for T-cell independent induction of IFN-gamma and development of Th1 responses essential for defense against intracellular pathogens. STAT4-deficient mice show impaired IL-12-induced Th1 development and enhanced Th2 development. Studies indicate IFN-α/β activation of STAT4 is required for IFN-γ production in response to viral infection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.