Thermo Fisher Scientific Huntingtin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from the date of receipt.

Target Information

Huntingtin is a disease gene linked to Huntington’s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. The disease is caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, resulting in a polyglutamine repeat in the protein product.

HD is a mid-life onset autosomal dominant neurodegenerative disease characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death within 10–20 years.

The huntingtin locus spans approximately 180 kb and consists of 67 exons. The gene is widely expressed and required for normal development, producing two alternatively polyadenylated transcripts (~13.7 kb and ~10.3 kb) with tissue-specific expression patterns.

The genetic defect in Huntington’s disease may not eliminate transcription but may confer new properties on the mRNA or alter protein function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.