Thermo Fisher Scientific Huntingtin Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

Huntingtin is a disease gene linked to Huntington’s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product.
HD is a mid-life onset autosomal dominant neurodegenerative disease characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10–20 years.
The huntingtin locus spans 180 kb and consists of 67 exons. The gene is widely expressed and required for normal development. It is expressed as two alternatively polyadenylated forms with different abundance in fetal and adult tissues. The larger transcript (~13.7 kb) is predominant in brain, while the smaller (~10.3 kb) is more widely expressed.
The genetic defect leading to Huntington’s disease may not eliminate transcription but may alter mRNA or protein function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.