Thermo Fisher Scientific CFTR Polyclonal Antibody

Applications

• Western Blot (WB): 1:200
• Immunohistochemistry (IHC): Assay-dependent

Product Specifications

Product Specific Information

Reconstitution: 25 µL, 50 µL, or 0.2 mL double distilled water (DDW), depending on sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and keep at -20°C.
Avoid multiple freeze/thaw cycles. Centrifuge antibody preparations before use (10,000 × g, 5 min).

Target Information

Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-regulated chloride channel.
Approximately 70% of CF cases involve deletion of phenylalanine at position 508 (ΔF508), leading to abnormal chloride transport.
CF mutation is typically lethal due to lung and liver disease.
Interestingly, Salmonella typhi utilizes CFTR to enter intestinal epithelial cells, and ΔF508 heterozygote/homozygote mice show 86% and 100% reductions in S. typhi intestinal uptake.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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