Thermo Fisher Scientific CFTR Polyclonal Antibody
CFTR 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody. Western blot 및 IHC에 사용 가능하며, 인간·마우스·랫트 반응성. 항원 친화 크로마토그래피로 정제된 고품질 연구용 항체로, -20°C 보관 권장.
- 카탈로그번호
- ACL-006-xxxxx (3개 옵션)
- 판매단위
- pk
카탈로그
3개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CFTR Polyclonal Antibody
Applications
- Western Blot (WB): 1:200
- Immunohistochemistry (IHC): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | (C)KEETEEEVQDTRL, corresponding to amino acid residues 1468–1480 of human CFTR, Cytoplasmic, C-terminal part |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.8 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitution: 25 µL, 50 µL, or 0.2 mL double distilled water (DDW), depending on sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and keep at -20°C.
Avoid multiple freeze/thaw cycles. Centrifuge antibody preparations before use (10,000 × g, 5 min).
Target Information
Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-regulated chloride channel.
Approximately 70% of CF cases involve deletion of phenylalanine at position 508 (ΔF508), leading to abnormal chloride transport.
CF mutation is typically lethal due to lung and liver disease.
Interestingly, Salmonella typhi utilizes CFTR to enter intestinal epithelial cells, and ΔF508 heterozygote/homozygote mice show 86% and 100% reductions in S. typhi intestinal uptake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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