Thermo Fisher Scientific Phospho-PLCg2 (Tyr759) Recombinant Rabbit Monoclonal Antibody (PLCG2Y759-G3)
Phospho-PLCγ2 (Tyr759)을 인식하는 Thermo Fisher의 재조합 토끼 단클론 항체로, Western blot 및 유세포분석에 적합합니다. 높은 특이성과 재현성을 제공하며, 다양한 포유류 시료에 반응합니다. 단백질 A/G로 정제된 액상 형태로 제공됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Flow Cytometry (Flow) | 1–1,000 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PLCG2Y759-G3 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr759 of human phospho PLCγ2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2896854 |
Additional Formats
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed, and individual clones are screened to select optimal candidates for production.
Advantages of recombinant rabbit monoclonal antibodies include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in receptor-mediated signal transduction by generating two second messengers, inositol 1,4,5-triphosphate and diacylglycerol, from phosphatidylinositol 4,5-bisphosphate.
There are multiple mammalian PLC isozymes, including PLCβ1–4, PLCγ1–2, PLCδ1–2, and PLCε. PLCδ isoforms, particularly PLCδ1, act as calcium signal amplifiers and are activated by atypical GTP-binding proteins. PLCδ1 is an effector in oxytocin receptor and α1B-adrenoreceptor signaling and is highly expressed in brain, heart, lung, and testis.
Abnormal accumulation of PLCδ has been observed in Alzheimer’s disease brains, suggesting a role in its pathology. PLCδ2 expression is associated with intestinal metaplasia and adenocarcinoma, potentially serving as a marker for gastric malignant transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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