Thermo Fisher Scientific GNB1L Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL
• Publications: [References not provided]

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200
• Publications: [References not provided]

Product Specifications

Product Specific Information

Immunogen sequence:
VDSVCLESVG FCRSSILAGG QPRWTLAVPG RGSDEVQILE MPSKTSVCAL KPKADAKLGM PMCLRLWQAD CSSRPLLLAG YEDGSVVL

Highest antigen sequence identity to orthologs:

• Mouse: 77%
• Rat: 78%

Target Information

GNB1L is a G-protein beta-subunit-like polypeptide belonging to the WD repeat protein family. WD repeats are conserved regions of approximately 40 amino acids, typically bracketed by gly-his and trp-asp (GH-WD), facilitating the formation of heterotrimeric or multiprotein complexes.

Members of this family are involved in various cellular processes, including:

• Cell cycle progression
• Signal transduction
• Apoptosis
• Gene regulation

This protein contains six WD repeats and is highly expressed in the heart. The gene maps to chromosome 22q11, a region associated with DiGeorge syndrome, derivative 22 syndrome, and cat-eye syndrome. Therefore, GNB1L may contribute to the etiology of these disorders.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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