Thermo Fisher Scientific COMMD1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
AQDTFHGYPG ITEELLRSQL YPEVPPEEFR PFLAKMRGIL KSIASADMDF NQLEAFLTAQ TKKQGGITSD QAAV

Antigen sequence identity:

• Mouse: 89%
• Rat: 92%

Target Information

Proposed scaffold protein implicated in diverse physiological processes, partly through regulation of ubiquitination of specific cellular proteins.

• Modulates cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1.
• Promotes ubiquitination and proteasomal degradation of NF-kappa-B subunit RELA, down-regulating NF-kappa-B activity.
• Regulates membrane expression and ubiquitination of SLC12A2 and ENaC subunits, influencing Na⁺ transport in epithelial cells.
• Promotes CFTR cell surface expression through regulation of ubiquitination.
• Down-regulates SOD1 activity by interfering with its homodimerization.
• Plays a role in copper ion homeostasis and ATP7A trafficking, interacting with the CCC and WASH complexes.
• Binds one copper ion per monomer and may facilitate biliary copper excretion.
• Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).
• Regulates HIF1A-mediated transcription by competing with ARNT/Hif-1-beta for HIF1A binding, reducing DNA binding and transcriptional activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.