Thermo Fisher Scientific SYNPO Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (IHC)

-

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Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

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Immunohistochemistry (Frozen) (IHC (F))

-

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Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

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Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SYNPO. Recombinant protein control fragment (Product #RP-95703). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Synaptopodin,uniProtId:Q8N3V7-1,ncbiNodeId:9606,antigenRange:460-548,antigenLength:929,antigenImageFileName:PA5-56997_Synaptopodin_Q8N3V7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-56997_Synaptopodin_Q8N3V7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648146

Product Specific Information

Immunogen sequence: TTPTKVYSEV HFTLAKPPSV VNRTARPFGI QAPGGTSQME RSPMLERRHF GEKAPAPQPP SLPDRSPRPQ RHIMSRSPMV ERRMMGQRS

Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 79%.

Target Information

SYNPO (Synaptopodin) is an actin-associated protein in telencephalic dendrites and renal podocytes. SYNPO is tightly associated with the dendritic spine apparatus, and mice lacking the SYNPO gene lack the apparatus. These SYNPO- mice also demonstrate an impaired ability to express long-term potentiation as well as deficits in spatial memory tasks, indicating that SYNPO is involved in the regulation of synaptic plasticity. Recent studies suggest that SYNPO is linked to neuronal calcium stores and plays a role in the calcium store-associated ability of neurons to undergo long-term plasticity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.