Thermo Fisher Scientific FOXP2 Chimeric Recombinant Rabbit Monoclonal Antibody (RAB-S249)
FOXP2 단백질을 특이적으로 인식하는 Thermo Fisher Scientific의 재조합 토끼 단일클론 항체. ICC, Flow Cytometry, ELISA, IP 등 다양한 연구용 응용에 적합. HEK293 세포에서 발현된 비결합형 항체로, 고순도 Protein A 정제 제품. 인간 FOXP2 단백질 연구용.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 1:100 |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | RAB-S249 |
| Immunogen | Recombinant antibody (rAb) phage display recognizing FOXP2 protein under non-denaturing conditions |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074786 |
Product Specific Information
- Specificity: Recognizes FOXP2 (Forkhead box protein P2), binding to a folded domain (amino acids 306–411).
- Function: FOXP2 acts as a transcriptional repressor involved in lung epithelium specification and differentiation.
Target Information
FOXP2 belongs to the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain, lung, and gut. The protein contains a FOX DNA-binding domain and a polyglutamine tract, functioning as a conserved transcription factor that may regulate 300–400 gene promoters in the human genome.
FOXP2 is essential for the development of speech and language regions in the brain during embryogenesis and may influence language-related biological pathways. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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