Thermo Fisher Scientific CD38 Chimeric Recombinant Rabbit Monoclonal Antibody (OKT10)

Applications

Product Specifications

Product Specific Information

This antibody recognizes an antigenic structure of a 45,000 daltons type II transmembrane glycoprotein present on human precursor B cells and T cells, activated T cells, natural killer cells, and some monocytes, myeloblasts, and erythroblasts. It strongly reacts with the surface membrane of plasma cells.

Target Information

CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein that induces activation, proliferation, and differentiation of mature lymphocytes and mediates apoptosis of myeloid and lymphoid progenitor cells. It functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and NAD+ glycohydrolase, or as a cell surface receptor.

Antibodies to CD38 are useful in:

• Subtyping of lymphomas and leukemias
• Detection of plasma cells (e.g., identification of myelomas)
• Marker for activated B and T cells

CD38 also participates in cell adhesion, signal transduction, and calcium signaling, and is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma. Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.