Thermo Fisher Scientific Aminoacylase Polyclonal Antibody
Rabbit polyclonal antibody recognizing human, mouse, and rat Aminoacylase (ACY1). Validated for WB, IHC, and ICC applications. Supplied as liquid, 1 mg/mL, purified by antigen affinity chromatography. Suitable for cytoplasmic detection in multiple tiss...
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within Human ACY-1 amino acids 50–250 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2913243 |
Product Specific Information
- Positive Control: Rat kidney tissue, mouse kidney tissue, rat brain tissue, human liver cancer tissue, human kidney tissue, human small intestine tissue, mouse liver tissue
- Subcellular Location: Cytoplasm
Target Information
ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group. It is involved in the catabolism and salvage of acylated amino acids. The gene is located on chromosome 3p21.1, a region associated with small-cell lung cancer (SCLC), where its expression is often reduced or undetectable. Human aminoacylase-1 shows high homology with the porcine enzyme and is the first member of a family of zinc-binding enzymes. Mutations in ACY1 cause aminoacylase-1 deficiency, a metabolic disorder characterized by CNS defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing produces multiple transcript variants, and read-through transcription occurs with the upstream ABHD14A gene. A related pseudogene exists on chromosome 18.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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