Thermo Fisher Scientific CLSTN1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 29-350 of human CLSTN1 (NP_055759.3). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CLSTN1,uniProtId:O94985-1,ncbiNodeId:9606,antigenRange:29-350,antigenLength:981,antigenImageFileName:PA5-109556_CLSTN1_O94985-1_Rabbit.svg,antigenImageFileNamePDP:PA5-109556_CLSTN1_O94985-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.04 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2854967

Product Specific Information

Immunogen sequence: ARVNKHKPWL EPTYHGIVTE NDNTVLLDPP LIALDKDAPL RFAGEICGFK IHGQNVPFDA VVVDKSTGEG VIRSKEKLDC ELQKDYSFTI QAYDCGKGPD GTNVKKSHKA TVHIQVNDVN EYAPVFKEKS YKATVIEGKQ YDSILRVEAV DADCSPQFSQ ICSYEIITPD VPFTVDKDGY IKNTEKLNYG KEHQYKLTVT AYDCGKKRAT EDVLVKISIK PTCTPGWQGW NNRIEYEPGT GALAVFPNIH LETCDEPVAS VQATVELETS HIGKGCDRDT YSEKSLHRLC GAAAGTAELL PSPSGSLNWT MGLPTDNGHD SD

Target Information

CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.