Thermo Fisher Scientific HEF1 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: BCL-1
• Predicted reactivity: Mouse (85%), Rat (83%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

HEF-1 is a multifunctional protein involved in integrin-based signaling that affects cell motility, growth, apoptosis, and oncogenic transformation. The Cas family of docking proteins, including HEF1, are substrates of focal adhesion kinase (FAK) and Src family tyrosine kinases, both key targets for drug development. Overproduction of HEF1 increases expression of genes linked to motility and invasiveness, such as metalloproteinases, MLCK, p160ROCK, and ErbBi. HEF1 also mediates apoptosis in epithelial-derived cell lines (e.g., MCF7, HeLa). Overexpression of BCAR1 (p130Cas), a related protein, has been associated with tamoxifen resistance, emphasizing the importance of this protein family in cancer prognosis.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.