Thermo Fisher Scientific FGFR1 Monoclonal Antibody (VBS-7)
FGFR1 단백질을 검출하기 위한 Thermo Fisher Scientific의 단클론 항체(VBS-7)입니다. Western blot, IHC, ELISA 등 다양한 응용에 사용 가능하며, 인간 및 마우스를 포함한 여러 종에 반응합니다. 고순도 정제된 액상 형태로 -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | 2 publications |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:200 | - |
| Immunocytochemistry (ICC/IF) | - | 2 publications |
| Flow Cytometry (Flow) | - | 1 publication |
| ELISA | 0.1–1.0 µg/mL | - |
| Immunoprecipitation (IP) | 2–5 µg | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Chicken, Guinea pig, Human, Mouse, Rat |
| Published Species | Human, Mouse, Rabbit |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | VBS-7 |
| Immunogen | Bovine FGF Receptor 1 (flg) purified from bovine Coronary Venular Endothelial Cells (CVEC) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533011 |
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family (FGFR1–4), which are membrane-spanning tyrosine kinases serving as high-affinity receptors for 17 growth factors (FGF1–17). These receptors play crucial roles in biological processes such as mesoderm induction, cell growth, migration, organ formation, and bone development.
FGFR1 undergoes alternative splicing, producing multiple variants expressed differently during embryonic and adult stages. Mutations or defects in FGFR1 are linked to several disorders, including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome. Chromosomal aberrations involving FGFR1 are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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