Thermo Fisher Scientific Ataxin 1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 1:10–1:500

Product Specifications

Target Information

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem, and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I–III.
ADCAI is genetically heterogeneous, with five genetic loci (SCA1, 2, 3, 4, and 6) assigned to different chromosomes. ADCAII (SCA7) presents with retinal degeneration, and ADCAIII (SCA5) is often referred to as the pure cerebellar syndrome.
ADCA is caused by expansion of CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The diseased allele contains 41–81 CAG repeats compared to 6–39 in the normal allele and is associated with spinocerebellar ataxia type 1 (SCA1).
At least two transcript variants encoding the same protein have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.