Thermo Fisher Scientific HFE2 Monoclonal Antibody (OTI8F4), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

HFE2 is involved in iron metabolism and may participate in the signaling pathway that activates hepcidin or modulates its expression. It may also serve as a receptor for hepcidin.
Alternative splicing generates different isoforms. Mutations in this gene cause hemochromatosis type 2A (juvenile hemochromatosis), an early-onset autosomal recessive disorder characterized by severe iron overload, hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis, and cardiomyopathy, typically manifesting before age 30.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.