Thermo Fisher Scientific IRF3 Monoclonal Antibody (OTI2G6), TrueMAB
IRF3 단백질을 표적하는 Mouse IgG2b 단일클론 항체로, Western blot 및 Immunocytochemistry에 사용 가능. 인간 IRF3(aa 27-169) 재조합 단백질로 면역화. 동결건조 형태로 제공되며, PBS 버퍼와 trehalose 포함. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Immunocytochemistry (ICC/IF)
- Tested Dilution: Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2G6 |
| Immunogen | Human recombinant protein fragment (aa 27–169 of human IRF3, produced in E. coli) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
IRF3 (Interferon Regulatory Factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses.
It plays a critical role in innate immune defense against DNA and RNA viruses by regulating transcription of IFN-alpha, IFN-beta, and interferon-stimulated genes (ISG).
IRF3 is activated through phosphorylation by IKBKE and TBK1, leading to dimerization, nuclear localization, and association with CREB-binding protein to form DRAF1 complex, which activates type I IFN and ISG gene transcription.
Mutations in IRF3 can cause acute encephalopathy and herpes-specific infection-induced disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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