
Thermo Fisher Scientific TPSB2 Polyclonal Antibody
Thermo Fisher Scientific의 TPSB2 Polyclonal Antibody는 Mouse 시료에 반응하는 Goat 유래 IgG 항체로, Western Blot, IP, Neutralization 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 동결건조 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunoprecipitation (IP) | 25 µg/mL |
| Neutralization (Neu) | 3 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse Mast Cell Protease-6/Mcpt6 (Ala22–Ser276) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609200 |
Product Specific Information
- In direct ELISAs, approximately 35% cross-reactivity with recombinant human (rh) TPS-1 and rhTPS-B2 is observed.
- Less than 10% cross-reactivity with recombinant mouse MCP-7 is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
TPSB2 is a protein coding gene belonging to the tryptase family (peptidase family S1). Tryptases are active as heparin-stabilized tetramers and resistant to endogenous proteinase inhibitors.
These genes are located on chromosome 16p13.3 and share a highly conserved 3′ UTR with tandem repeat sequences that may regulate mRNA stability.
An intron upstream of the initiator Met codon separates transcription initiation from the coding sequence—a characteristic feature of tryptases.
Allelic variation in this gene led to the historical classification into βII and βIII forms.
Beta tryptases are predominant in mast cells, while alpha tryptases are found mainly in basophils.
Tryptases are implicated in asthma and other allergic or inflammatory disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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