Thermo Scientific™

TheraPure™ GMP Pyrophosphatase, inorganic, 0.1 U/μL

Thermo Scientific TheraPure GMP* Pyrophosphatase, inorganic, is manufactured to ICH Q7 GMP principles and supported by a comprehensive documentation package.자세히 알아보기

Thermo Scientific TheraPure GMP* Pyrophosphatase, inorganic, is manufactured to ICH Q7 GMP principles and supported by a comprehensive documentation package. It is specifically designed for the development and manufacturing of mRNA therapeutics and vaccines. Also known as inorganic diphoshatase or PPase, it catalyzes the hydrolysis of inorganic pyrophosphate (PPi) generated by in vitro transcription reactions into two orthophosphates (Pi):
P2O74- (PPi) + H2O → 2 HPO42- (2 Pi)

Designed for process development and manufacturing
TheraPure GMP Pyrophosphatase, Inorganic, helps accelerate mRNA vaccine and therapeutics production from preclinical development to commercialization by providing:
• Quality—meet critical product quality needs to help accelerate therapeutic development and manufacturing
• Minimal risk—help reduce risks in developing therapeutics by utilizing proven products
• Technical partnership—partner with expert product and technical support
• Secure and consistent supply—count on a secure and stable supply of product at a global scale

Comprehensive quality system
TheraPure GMP Pyrophosphatase is supported by a extensive quality system and documentation including:
• Manufactured to relevant ICH Q7 GMP guidelines
• Animal-origin free (AOF) manufacturing processes, materials, and facilities
• Validated manufacturing processes and analytical test methods
• Comprehensive impurity profiles
• Verified compendial assays where applicable
• Product stability data
• Tested by analytical methods following ICH Q2 guidelines whenever possible
• Drug master file (DMF)

Enzyme activity
One unit of enzyme catalyzes the hydrolysis of 1 μmol of inorganic pyrophosphate in 1 min at 25°C.

For additional TheraPure GMP products or customization, please visit www.thermofisher.com/therapure.

*TheraPure GMP refers to the quality level of the raw, ancillary, or starting materials to be used for further manufacturing. TheraPure GMP products are manufactured in facilities with ISO 9001–certified quality management systems that operate in accordance with relevant good manufacturing practice (GMP) principles, as outlined in ICH Q7 or equivalent guidance documents or standards.

사양

농도0.1 U/μL

색상Transparent

순도≥95%

pH7.1 to 7.9

용도(애플리케이션)In vitro transcription

보관 버퍼10 mM Tris-HCl pH 7.5, 0.1 mM EDTA, 5 mM DTT, 50% glycerol

발현 시스템E. coli

질량32 kDa

효소Pyrophosphatase

소스Saccharomyces cerevisiae

수량0.5 kU

제품 유형Pyrophosphatase

제품라인TheraPure™ GMP

생물학적 활성Pyrophosphatase

형태Liquid

Unit SizeEach