Thermo Fisher Scientific ABCA4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.5 µg/mL

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

ABCA4 (ATP-Binding Cassette, Subfamily A, Member 4), also known as ABCR, is a protein encoded by the ABCA4 gene in humans. It belongs to the ATP-binding cassette transporter gene sub-family A (ABC1), found exclusively in multicellular eukaryotes.
This gene is mapped to chromosome 1p21–p13 and is expressed exclusively in retinal photoreceptor cells, where it mediates transport of essential molecules across the photoreceptor cell membrane.
Immunofluorescence microscopy and Western blot analyses have shown that ABCR is present in foveal and peripheral cone, as well as rod photoreceptors. Loss of ABCR function is associated with Stargardt macular dystrophy due to foveal cone degeneration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.