Thermo Fisher Scientific BSEP Polyclonal Antibody
BSEP 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 적합하며, Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제된 동결건조 형태로 제공되며, 재구성 후 500 µg/mL 농도 유지.
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Thermo Fisher Scientific BSEP Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL | View 3 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL | View publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human ABCB11 (1175–1199aa KYGDNTKEIPMERVIAAAKQAQLHD). |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 4 mg trehalose |
| Contains | No preservative |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745806 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominantly in the liver, localized to the canalicular microvilli and subcanalicular vesicles of hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP-binding cassette (ABC) domain.
Defects in ABCB11 cause progressive familial intrahepatic cholestasis 2 (PFIC2), an inherited liver disease in childhood characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Mutations in ABCB11 are also associated with chronic intrahepatic cholestasis without familial history.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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