Thermo Fisher Scientific Daclizumab Chimeric Recombinant Mouse Monoclonal Antibody (Daclizumab)
Daclizumab 키메릭 재조합 마우스 단일클론 항체로 IL-2 수용체 p55 체인(Tac antigen)에 결합. 인간 및 원숭이 반응성. HEK293 세포에서 발현된 비접합 항체로, 단백질 A로 정제됨. 연구용으로 면역억제 및 세포 활성화 연구에 적합.
- 판매단위
- pk
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Thermo Fisher Scientific Daclizumab Chimeric Recombinant Mouse Monoclonal Antibody (Daclizumab)
Applications
- Flow Cytometry (Flow): Assay-dependent
- Inhibition Assays (IA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Cynomolgus monkey, Human, Rhesus monkey |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Daclizumab |
| Immunogen | Cultured T-cells derived from a patient with Mycosis fungoides |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
Product Specific Information
Binds to p55 chain of IL2R on human T cells (Tac antigen), which is expressed on T cells activated by mitogens, soluble antigens, and alloantigens but not on resting T cells, thymocytes, B cells, monocytes, activated B cells, leukemic T cell blasts from patients with acute lymphoblastic leukemia, and long-term T cell lines.
Target Information
Humanized IgG1 monoclonal antibody that binds to the human interleukin-2 receptor (anti-Tac or anti-CD25).
Daclizumab is composed of human (90%) and murine (10%) antibody sequences.
- Human sequences: derived from constant domains of human IgG1 and variable framework regions of Eu myeloma antibody
- Murine sequences: derived from complementarity-determining regions of a murine anti-Tac antibody
On April 22, 2008, Roche Registration Limited voluntarily withdrew marketing authorization for Zenapax (daclizumab), used for prophylaxis of acute organ rejection in renal transplantation, for commercial reasons not related to safety concerns.
Later, Biogen and Abbvie’s Zinbryta (daclizumab) was approved by the FDA in 2016 for the treatment of adult patients with relapsing forms of multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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