Thermo Fisher Scientific Abciximab Chimeric Recombinant Mouse Monoclonal Antibody (7E3 (Abciximab))
인간 CD41을 인식하는 Abciximab 키메라 재조합 마우스 단클론 항체입니다. 혈소판 GPIIb/IIIa 수용체에 결합하여 응집을 억제하며, vitronectin 및 Mac-1 수용체에도 작용합니다. HEK293 세포에서 발현된 비결합형 항체로, Protein A로 정제되었습니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Inhibition Assays (IA)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7E3 (Abciximab) |
| Immunogen | CD41 is the integrin alpha chain 2b forming a fibrinogen receptor in heterodimeric complex with beta 3. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
Product Specific Information
Recognises human CD41.
Target Information
Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3.
It binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules.
Additionally, it binds to the vitronectin (αvβ3) receptor found on platelets, endothelial, and smooth muscle cells.
Abciximab binding to the GPIIb/IIIa receptor involves steric hindrance or conformational changes that block access to the receptor, rather than direct interaction with the RGD binding site.
It also blocks the Mac-1 receptor on monocytes and neutrophils, thereby inhibiting monocyte adhesion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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