Thermo Fisher Scientific Gemtuzumab Chimeric Recombinant Mouse Monoclonal Antibody (hP67.6 (Gemtuzumab))
인간 CD33을 인식하는 재조합 키메라 마우스 단클론 항체입니다. 면역세포 분석 및 세포 표지에 적합하며, HEK293 세포에서 발현되었습니다. 단백질 A로 정제된 액상 형태로 제공되며, 연구용으로만 사용 가능합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: Assay-dependent
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | hP67.6 (Gemtuzumab) |
| Immunogen | Gemtuzumab was generated by humanization of the murine P67.6 clone, raised against CD33-transfected FMY9S5 cells of human origin. CD33 is a transmembrane receptor expressed predominantly on cells of the myeloid lineage, but it can also be found on some lymphoid cells. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
Product Specific Information
Recognises human CD33.
Target Information
Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody conjugated with a calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from Micromonospora echinospora ssp. calichensis. Approximately 50% of the antibody is loaded with 4–6 moles of calicheamicin per mole of antibody. The antibody specifically targets the CD33 antigen present on leukemic myeloblasts in most patients with acute myeloid leukemia (AML). By binding to CD33, the cytotoxic agent inhibits tumor cell growth and induces cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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