Thermo Fisher Scientific PD-L1 Monoclonal Antibody (22E1), MonoRab

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1-5 µg/mL

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

22E1

Immunogen

Carrier protein -coupled synthetic peptide within C-terminus of human PD-L1 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PD-L1 (CD274),uniProtId:Q9NZQ7-1,ncbiNodeId:9606,antigenRange:290,antigenLength:290,antigenImageFileName:A02013-40_PD-L1_CD274_Q9NZQ7-1_Rabbit.svg,antigenImageFileNamePDP:A02013-40_PD-L1_CD274_Q9NZQ7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Wet ice

Product Specific Information

Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/ml.

Programmed cell death 1 ligand 1 is one of the two ligands of PD-1. PD-L1 is expressed on macrophages, T cells, B cells, NK cells, DCs and some cancer cell surface. Binding of PD-1 with PD-L1 could result in down-regulation of the immune system by inhibiting the T-cell activation process. Thus, PD-L1 is an important immune checkpoint and popular target for therapeutic antibodies against many cancers. GenScript MonoRab™ Human PD-L1 Antibody(22E1), mAb, Rabbitis produced from cell culture in vitro under conditions free from animal-derived components.

Target Information

Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.