Thermo Fisher Scientific PD-L1 Monoclonal Antibody (22E1), MonoRab

Applications

• Immunohistochemistry (Paraffin) (IHC (P))

Tested Dilution

• 1–5 µg/mL

Product Specifications

Product Specific Information

Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/mL.
Programmed cell death 1 ligand 1 (PD-L1) is one of the two ligands of PD-1. PD-L1 is expressed on macrophages, T cells, B cells, NK cells, DCs, and some cancer cell surfaces. Binding of PD-1 with PD-L1 results in down-regulation of the immune system by inhibiting T-cell activation.
PD-L1 is an important immune checkpoint and a popular target for therapeutic antibodies against many cancers.
GenScript MonoRab™ Human PD-L1 Antibody (22E1), mAb, Rabbit is produced from cell culture in vitro under conditions free from animal-derived components.

Target Information

Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a B7 family member. The specific receptor, programmed death receptor 1 (PD-1), negatively regulates T-cell receptor (TCR) signaling.
Upon ligation, PD-L1 decreases TCR-mediated proliferation and cytokine production. PD-L1 expression is abundant in many murine and human cancers and can be up-regulated upon IFN-γ stimulation.
PD-L1 plays a key role in tumor immune evasion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.