Thermo Fisher Scientific ABCB11 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:2,500-1:5,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ABCB11. Recombinant protein control fragment (Product #RP-101754). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:BSEP,uniProtId:O95342-1,ncbiNodeId:9606,antigenRange:616-746,antigenLength:1321,antigenImageFileName:PA5-53899_BSEP_O95342-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53899_BSEP_O95342-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.48 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2637530

Product Specific Information

Immunogen sequence: RLSTVRAADT IIGFEHGTAV ERGTHEELLE RKGVYFTLVT LQSQGNQALN EEDIKDATED DMLARTFSRG SYQDSLRASI RQRSKSQLSY LVHEPPLAVV DHKSTYEEDR KDKDIPVQEE VEPAPVRRIL K

Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 79%.

Target Information

ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.