Thermo Fisher Scientific TET1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TET1. Recombinant protein control fragment (Product #RP-92566). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TET1,uniProtId:Q8NFU7-1,ncbiNodeId:9606,antigenRange:435-578,antigenLength:2136,antigenImageFileName:PA5-53896_TET1_Q8NFU7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53896_TET1_Q8NFU7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648387

Product Specific Information

Immunogen sequence: VPPNPIATFN APSKWPEPQS TVSYGLAVQG AIQILPLGSG HTPQSSSNSE KNSLPPVMAI SNVENEKQVH ISFLPANTQG FPLAPERGLF HASLGIAQLS QAGPSKSDRG SSQVSVTSTV HVVNTTVVTM PVPMVSTSSS SYTT

Highest antigen sequence identity to the following orthologs: Mouse - 46%, Rat - 47%.

Target Information

Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.